My PCP doc got my insurance to pay for a follow up sleep study and I have it scheduled about three weeks from now. I'm also on their cancel list so hopefully I'll get in sooner. My doctor's assistant called and left voice mail for me stating that I was to stop taking my Provigil two weeks before doing the sleep study. Didn't say why and it's difficult at best to get her on the phone and I suspect she wouldn't have a good answer anyway. After spending some time with Google, I cannot find anyone else receiving this kind of advice.

Not taking Provigil may not be an option. I currently take 400mg per day and it just barely keeps me awake. The fatigue, sleepiness, brain fog, are all still there and if I stop taking Provigil I might as well take a leave of absence from work because I wouldn't be able to function. I'm sure they think the Provigil will keep me up during the study but I have no problem taking 400mg in the morning and having a nap in the afternoon. Nothing keeps me from going to sleep and I will abstain on the day of the sleep study. That's good enough, right? Anyone else told stay away from stimulants for that long before a sleep study? I know my PCP doesn't know much about OSA or sleep studys and I will be taking my results to a sleep specialist, not the PCP.

My guess would be they want all of the Provigil out of your body before the sleep study.  Drugs stay in your system long after you stop feeling the effects.  I've recently learned that drugs have a much greater affect on our sleep than I ever imagined.  I'm on a medication that is known to delay or completely suppress REM.  It doesn't "make me drowsy", but it's likely affecting my sleep which is resulting in a high level of fatigue for me.

If I were in your situation, I would get in touch with the sleep doc now to discuss the situation.

Provigil's half-life is 15 hours. My last dose will be at least 36 hours before the sleep study. Maybe I'll try 2 full days before the study. And I think I will try to see the sleep specialist before the study.

You're quite right the half-life is 15 hours.  I'm female and I have had doctors tell me I need to be off certain medications for 3 months before trying to get pregnant.  When you know the half-life of a drug is in hours, 3 months sounds pretty extreme.  I'm pretty sure it's because of the elimination time.  If I'm interpreting the Provigil prescribing information right, it looks like 81% is eliminated after 11 days:  In a clinical study using radiolabeled modafinil, a total of 81% of the administered radioactivity was recovered in 11 days post-dose...

Maybe your GP's concern is this elimination time.  I do hope you are able to see the sleep specialist ahead of time because he would know much better if the Provigil will affect the study.  He might tell you it won't affect the study at all and you can take it on the actual day.  That would be nice  

Maybe if you can't get an appointment, he can at least advise you regarding the Provigil.  It sure sounds like two weeks without it would be terribly difficult for you.

It's not a reasonable request.   Especially not two weeks.  That's more than enough time to become unemployed in because you can't stay awake.    

I met with a sleep specialist before my studies and they had no problem me taking provigil the same morning as the study.  It was a lower dose thanyou take.

You could try talking to your doctor before hand to see if he has any specific reason for his request  and then try and figure out whether he knows what he's talking about.   As a PCP he's unlikely to know a lot about either provigil or sleep studies but maybe he does have a reason.